Treatment of choice for high risk basal cell carcinoma (BCC) of the face is Mohs micrographic surgery. Radiotherapy can be applied when surgery will result in cosmetic and/or functional morbidity. Patients with locally advanced or metastatic BCC can be treated with vismodegib or sonidegib. R-CHOP is used frequently in the treatment of several B-cell non-Hodgkin lymphomas, but effectiveness in the treatment of BCC is unknown. Here we present an impressive clinical and histological response of a locally advanced BCC of the face after treatment with R-CHOP for diffuse large B-cell lymphoma.